Tissue expression
Cell line expression
Protein structure
NELFA
Negative elongation factor complex member ANELF-A, WHSC2
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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antibodies-online | ABIN1724801 | 2 references | Monoclonal |
WB
EL
ICC
IHC
FC
|
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GeneTex | GTX60732 | Monoclonal |
WB
EL
ICC
IHC
FC
|
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Proteintech Group | 10456-1-AP | 5 references | Polyclonal |
WB
EL
ICC
IP |
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Novus Biologicals | NBP2-37394 | Monoclonal |
WB
EL
ICC
IHC
FC
|
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Invitrogen Antibodies | MA5-17199 | Monoclonal |
WB
EL
ICC
IHC
FC
|
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