APR00489G

antibody from Leading Biology

Targeting: S1PR1 CD363, D1S3362, edg-1, EDG1

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APR00489G

Provider

Leading Biology

Product name

Sphingosine 1-Phosphate Receptor 1 (extracellular) Antibody

Antibody type

Polyclonal

Description

Lysophospholipids constitute a group of important lipid mediators; lysophosphatidic acid (LPA) a glycerolysophospholipid and sphingosine 1-phosphate (SIP), a lysosphingolipid. Sphingosine 1-phosphate is a bioactive lipid derived from metabolism of sphingomyelin1. Sphingosine 1-phosphate is implicated in the regulation of many cellular functions including proliferation, apoptosis, survival, adhesion, differentiation, and migration2. Sphingosine 1-phosphate exerts its activity through five distinct G-protein-coupled receptors, (also named endothelial differentiation gene receptors - EDG); S1PR1 (EDG-1), S1PR2 (EDG-5), S1PR3 (EDG-3), S1PR4 (EDG-6), and S1PR5 (EDG-8)3. Sphingosine 1-Phosphate Receptor 1 (S1PR1) is ubiquitously expressed. S1PR1 mRNA is detected in the brain, heart, spleen, liver, lung, thymus, kidney, skeletal muscle and lymphoid tissues4.Knockout of the gene encoding S1PR1 is lethal and therefore makes in vivo studies difficult 5. Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of the human Sphingosine 1-Phosphate Receptor 1. Anti-Sphingosine 1-Phosphate Receptor 1 (extracellular) antibody, (#AG1015) can be used in western blot analysis, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize Sphingosine 1-Phosphate Receptor 1 from human, rat and mouse samples.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.