14961-1-AP

antibody from Proteintech Group

Targeting: RAD51 BRCC5, FANCR, HsRad51, HsT16930, RAD51A, RECA

Provider product page for 14961-1-AP

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Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [31]
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Validations
Western blot [1]

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Product number: 14961-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14961-1-AP, RRID:AB_2177083
Product name: RAD51 antibody
Antibody type: Polyclonal
Description: KD/KO validated RAD51 antibody (Cat. #14961-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

RAD51 protein structure - 14961-1-AP shown in red.

Submitted references Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca²⁺]_m-PDP1-PDH-histone acetylation retrograde signaling.

Shi Y, Wang Y, Jiang H, Sun X, Xu H, Wei X, Wei Y, Xiao G, Song Z, Zhou F
Cell death & disease 2021 Sep 6;12(9):837

Predictive value of RAD51 on the survival and drug responsiveness of ovarian cancer.

Feng Y, Wang D, Xiong L, Zhen G, Tan J
Cancer cell international 2021 May 5;21(1):249

HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance.

Zong B, Sun L, Peng Y, Wang Y, Yu Y, Lei J, Zhang Y, Guo S, Li K, Liu S
Oncology reports 2021 Jul;46(1)

AEG-1 Knockdown Sensitizes Glioma Cells to Radiation Through Impairing Homologous Recombination Via Targeting RFC5.

Zhao X, Sun Y, Sun X, Li J, Shi X, Liang Z, Ma Y, Zhang X
DNA and cell biology 2021 Jul;40(7):895-905

MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways.

Zhou S, Dai Z, Wang L, Gao X, Yang L, Wang Z, Wang Q, Liu Z
Journal of cellular and molecular medicine 2021 Dec;25(24):11157-11169

BRD4 inhibition sensitizes cervical cancer to radiotherapy by attenuating DNA repair.

Ni M, Li J, Zhao H, Xu F, Cheng J, Yu M, Ke G, Wu X
Oncogene 2021 Apr;40(15):2711-2724

CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation.

Liao Y, Hua Y, Li Y, Zhang C, Yu W, Guo P, Zou K, Li W, Sun Y, Wang R, Zuo Y, Sui S, Tian C, Hao J, Chen M, Hu S, Chen M, Long Q, Wang X, Zou L, Xie F, Guo W, Deng W
Cell death and differentiation 2021 Apr;28(4):1347-1363

MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.

Peng S, Sun Y, Luo Y, Ma S, Sun W, Tang G, Li S, Zhang N, Ren J, Xiao Y, Liu X, Zhang J, Gong Y, Xie C
International journal of biological sciences 2020;16(12):2145-2158

Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer.

Zhong L, Wang R, Wang Y, Peng S, Ma Y, Ding S, Yang H, Chen S, Luo X, Wang W
Neoplasia (New York, N.Y.) 2020 Sep;22(9):365-375

Inhibition of survivin induces spindle disorganization, chromosome misalignment, and DNA damage during mouse embryo development.

Pan MH, Ju JQ, Li XH, Xu Y, Wang JD, Ren YP, Lu X, Sun SC
Cell cycle (Georgetown, Tex.) 2020 Sep;19(17):2148-2157

CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos.

Ju JQ, Li XH, Pan MH, Xu Y, Sun MH, Xu Y, Sun SC
Cell proliferation 2020 Oct;53(10):e12895

YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization.

Zhao L, Li R, Qiu JZ, Yu JB, Cao Y, Yuan RT
Molecular and cellular probes 2020 Oct;53:101577

UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.

Sun J, Zhu Z, Li W, Shen M, Cao C, Sun Q, Guo Z, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2020 Oct 21;39(1):222

Cell type-specific genotoxicity in estrogen-exposed ovarian and fallopian epithelium.

Song L, Tang Z, Peng C, Yang Y, Guo C, Wang D, Guo L, Chen J, Liu C
BMC cancer 2020 Oct 21;20(1):1020

Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma.

Yang XZ, Chen XM, Zeng LS, Deng J, Ma L, Jin C, Wang R, Wang MH, Wen YF, Wu XL, Wang HY, Cui SZ
Aging 2020 Oct 17;12(20):20380-20395

DNA methylation‑regulated miR‑155‑5p depresses sensitivity of esophageal carcinoma cells to radiation and multiple chemotherapeutic drugs via suppression of MAP3K10.

Luo W, Zhang H, Liang X, Xia R, Deng H, Yi Q, Lv L, Qian L
Oncology reports 2020 May;43(5):1692-1704

β-Elemene enhances radiosensitivity in non-small-cell lung cancer by inhibiting epithelial-mesenchymal transition and cancer stem cell traits via Prx-1/NF-kB/iNOS signaling pathway.

Zou K, Li Z, Zhang Y, Mu L, Chen M, Wang R, Deng W, Zou L, Liu J
Aging 2020 Dec 9;13(2):2575-2592

Berberine attenuates XRCC1-mediated base excision repair and sensitizes breast cancer cells to the chemotherapeutic drugs.

Gao X, Wang J, Li M, Wang J, Lv J, Zhang L, Sun C, Ji J, Yang W, Zhao Z, Mao W
Journal of cellular and molecular medicine 2019 Oct;23(10):6797-6804

MiR-34s negatively regulate homologous recombination through targeting RAD51.

Chen S, Liu R, Wang Q, Qi Z, Hu Y, Zhou P, Wang Z
Archives of biochemistry and biophysics 2019 May 15;666:73-82

Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer.

Li Y, Kong R, Chen H, Zhao Z, Li L, Li J, Hu J, Zhang G, Pan S, Wang Y, Wang G, Chen H, Sun B
Aging 2019 Jul 21;11(14):5035-5057

Triptolide interferes with XRCC1/PARP1-mediated DNA repair and confers sensitization of triple-negative breast cancer cells to cisplatin.

Zhang Z, Sun C, Zhang L, Chi X, Ji J, Gao X, Wang Y, Zhao Z, Liu L, Cao X, Yang Y, Mao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:1541-1546

RDM1 promotes critical processes in breast cancer tumorigenesis.

Chen Y, Sun Z, Zhong T
Journal of cellular and molecular medicine 2019 Aug;23(8):5432-5439

LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA.

Shen L, Wang Q, Liu R, Chen Z, Zhang X, Zhou P, Wang Z
Nucleic acids research 2018 Jan 25;46(2):717-729

Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.

Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, Jiang H, Xie C, Zhou Y, Zhou F
Journal of Cancer 2017;8(8):1400-1409

IER5 is involved in DNA Double-Strand Breaks Repair in Association with PAPR1 in Hela Cells.

Yu XP, Wu YM, Liu Y, Tian M, Wang JD, Ding KK, Ma T, Zhou PK
International journal of medical sciences 2017;14(12):1292-1300

Inhibition of Rad51 sensitizes breast cancer cells with wild-type PTEN to olaparib.

Zhao Q, Guan J, Zhang Z, Lv J, Wang Y, Liu L, Zhou Q, Mao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Oct;94:165-168

Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.

Guan J, Zhao Q, Lv J, Zhang Z, Sun S, Mao W
Oncology letters 2017 Oct;14(4):4965-4970

Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation.

Guan J, Zhao Q, Mao W
Biochimica et biophysica acta 2016 Dec;1863(12):3106-3115

Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.

Song X, Shi Q, Liu Z, Wang Y, Wang Y, Song E, Song Y
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193

5-Azacytidine enhances the radiosensitivity of CNE2 and SUNE1 cells in vitro and in vivo possibly by altering DNA methylation.

Jiang W, Li YQ, Liu N, Sun Y, He QM, Jiang N, Xu YF, Chen L, Ma J
PloS one 2014;9(4):e93273

Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression.

Groselj B, Kerr M, Kiltie AE
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 Sep;108(3):429-33

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The RAD51 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RAD51. This antibody recognizes human, mouse, rat antigen. The RAD51 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14961-1-AP.pdf

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