NR2C1

This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Description

Nuclear receptor subfamily 2 group C member 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cell Junctions, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

12 (95020229 - 95073628)

Ensembl ID

ENSG00000120798  (ver. 103.38)

Orthologs

Mouse Nr2c1: ENSMUSG00000005897

UniProt

P13056

neXtProt

NX_P13056

Human splice variants
Mouse splice variants

Protein structure