IL9R

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Interleukin 9 receptor

Tissue specificity

Tissue enhanced (lymphoid tissue, urinary bladder)

Predicted location

Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

X (155997581 - 156010817)

Ensembl ID

ENSG00000124334  (ver. 103.38)

Orthologs

Mouse Il9r: ENSMUSG00000020279

UniProt

Q01113

neXtProt

NX_Q01113

Human splice variants
Mouse splice variants

Protein structure