CCNB3

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Description

Cyclin B3

Tissue specificity

Group enriched (brain, epididymis, testis)

Subcell location

Nuclear speckles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

X (50202713 - 50351914)

Ensembl ID

ENSG00000147082  (ver. 103.38)

Orthologs

Mouse Ccnb3: ENSMUSG00000051592

UniProt

Q8WWL7

neXtProt

NX_Q8WWL7

Human splice variants
Mouse splice variants

Protein structure