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- Antigen structure
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- Product number
- AF1824 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Complement Factor D/Adipsin Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human Complement Factor D in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant mouse Complement Factor D is observed, and less than 1% cross-reactivity with recombinant human (rh) Complement Factor B and rhComplement Factor I is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
P00746- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models.
Analysis of Factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement.
Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.
Crowley MA, Delgado O, Will-Orrego A, Buchanan NM, Anderson K, Jaffee BD, Dryja TP, Liao SM
Investigative ophthalmology & visual science 2018 Feb 1;59(2):940-951
Investigative ophthalmology & visual science 2018 Feb 1;59(2):940-951
Analysis of Factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement.
Pihl R, Jensen L, Hansen AG, Thøgersen IB, Andres S, Dagnæs-Hansen F, Oexle K, Enghild JJ, Thiel S
Journal of immunology (Baltimore, Md. : 1950) 2017 Aug 9;
Journal of immunology (Baltimore, Md. : 1950) 2017 Aug 9;
Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.
Degn SE, Jensen L, Hansen AG, Duman D, Tekin M, Jensenius JC, Thiel S
Journal of immunology (Baltimore, Md. : 1950) 2012 Oct 15;189(8):3957-69
Journal of immunology (Baltimore, Md. : 1950) 2012 Oct 15;189(8):3957-69
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