AIMP1

The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

Description

Aminoacyl tRNA synthetase complex interacting multifunctional protein 1

Tissue specificity

Low tissue specificity

Subcell location

Cytosol

Predicted location

Intracellular, Secreted to blood

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (106315544 - 106349456)

Ensembl ID

ENSG00000164022  (ver. 103.38)

Orthologs

Mouse Aimp1: ENSMUSG00000028029

UniProt

Q12904

neXtProt

NX_Q12904

Human splice variants
Mouse splice variants

Protein structure