HAUS3

This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Description

HAUS augmin like complex subunit 3

Tissue specificity

Low tissue specificity

Subcell location

Microtubules, Cytokinetic bridge, Mitotic spindle, Mitochondria

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (2078998 - 2242276)

Ensembl ID

ENSG00000214367  (ver. 103.38)

Orthologs

Mouse Haus3: ENSMUSG00000079555

UniProt

Q68CZ6

neXtProt

NX_Q68CZ6

Human splice variants
Mouse splice variants

Protein structure