CABT-B11979

antibody from Creative Diagnostics

Targeting: IRF7

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-B11979

Provider

Creative Diagnostics

Product name

Human anti-Human IRF-7 recombinant monoclonal antibody, clone SFB420 [PE]

Antibody type

Monoclonal

Description

It recognozes the interferon regulatory factor 7 (IRF-7) phosphorylated at serines 477 and 479 (pS477/pS479). IRF-7 is a member of the IRF family of transcription factors and a key player in the innate immune response against viral infections. Constitutive expression of IRF-7 is limited to peripheral blood lymphocytes and dendritic cells while in most cell types its expression can be induced by type I interferon. IRF-7 is sequestered in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling, it becomes phosphorylated by TBK and IKK-i kinases. Phosphorylated IRF-7 migrates in the nucleus where it can activate interferon type I genes and other interferon-stimulated genes. Additional information: It displays negligible binding to Fc receptors.

Reactivity

Human

Host

Human

Conjugate

Yellow dye

Isotype

IgG

Antibody clone number

SFB420

Vial size

for 100 tests

Storage

Store protected from light at 2ÿ8 °C. Do not freeze.