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Protein structure
TCF3
Transcription factor 3bHLHb21, E2A, E47, ITF1, MGC129647, MGC129648, p75, VDIR
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]
Top validated antibodies |
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| Proteintech Group |  21242-1-AP |
6 references | Polyclonal |
WB
EL
ICC
IP
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| LSBio | LS-C108663 |
Polyclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | 21242-1-AP |
Polyclonal |
WB
ICC
IP
OA
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| GeneTex | GTX31402 |
Polyclonal |
WB
EL
ICC
IHC
|
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| Novus Biologicals | H00006929-M01 |
1 references | Monoclonal |
WB
EL
ICC
|
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