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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 313302 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#313302, RRID:AB_314987
- Product name
- Purified anti-human CD135 (Flt-3/Flk-2)
- Antibody type
- Monoclonal
- Antigen
- BV-173 pro-B cell line
- Description
- CD135 is a 130-160 type III tyrosine kinase receptor expressed on CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML-BC. CD135, also known as FMS-like tyrosine kinase-3, FLT3, STK-1, and Flk-2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human pre-B leukemia cell line REH stained with purified BV10A4H2, followed by biotinylated anti-mouse IgG and Sav-PE
- Conjugate
- Unconjugated
