CABT-L1457

antibody from Creative Diagnostics

Targeting: MAP2K3 MAPKK3, MEK3, MKK3, PRKMK3

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-L1457

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human MEK3 monoclonal antibody, clone 2I9M25

Antibody type

Monoclonal

Description

MKK3 (MEK3) is a dual specificity protein kinase that belongs to the MAP kinase kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2I9M25

Concentration

0.5 mg/ml

Storage

-20°C, Avoid Freeze/Thaw Cycles