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- Antibody Data
- Antigen structure
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- Product number
- DCABH-2946 - Provider product page
- Provider
- Creative Diagnostics
- Proper citation
- Creative Diagnostics Cat#DCABH-2946, RRID:AB_2476824
- Product name
- Rabbit Anti-Human ITGA2B monoclonal antibody, clone KN22-20
- Antibody type
- Monoclonal
- Description
- Integrins are heterodimers composed of noncovalently associated transmembrane Ï« and ÉÇ subunits. The 16 Ï« and 8 ÉÇ subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors
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