60114AZ

antibody from STEMCELL Technologies Inc
Targeting: ITGA2B CD41, CD41B, GP2B, PPP1R93
Provider product page for 60114AZ
Immunocytochemistry
Immunohistochemistry
Flow cytometry
Blocking/Neutralizing

Antibody data

Product number
60114AZ - Provider product page
Provider
STEMCELL Technologies Inc
Product name
Anti-Human CD41 Antibody, Clone HIP8, APC
Antibody type
Monoclonal
Description
The HIP8 antibody reacts with the ~125 kDa GPIIb? subunit of human CD41, a heterodimeric integrin expressed primarily on platelets, megakaryocytes, monocytes, and acute megakaryoblastic leukemia cells. The GPIIb? subunit is linked to a smaller ~25 kDa subunit (GPIIb?) by a single disulfide bond. Three isoforms of CD41 that are generated by alternative splicing have been identified, one of which is expressed only by cancerous cells. CD41 associates non-covalently with CD61 (integrin b3) in a calcium-dependent manner to form the CD41/CD61 (or GPIIb/IIIa) complex, which has been identified as a receptor for several ligands, including fibrinogen, fibronectin, vitronectin, and thrombin. Binding to the CD41/CD61 complex involves an RGD tripeptidyl sequence in the ligand, and both ligand occupancy and ligand-mediated receptor clustering are functionally important in the integrin-mediated response. The HIP8 antibody reportedly blocks platelet aggregation and inhibits the activation of platelets by several compounds.
Reactivity
Human, Porcine
Isotype
IgG
Vial size
100 Tests
Storage
2 - 8°C
ITGA2B protein structure - 60114AZ shown in red.