SCRIB

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Description

Scribble planar cell polarity protein

Tissue specificity

Tissue enhanced (esophagus)

Subcell location

Nucleoplasm, Plasma membrane, Cell Junctions, Rods & Rings

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (143790920 - 143815773)

Ensembl ID

ENSG00000180900  (ver. 103.38)

Orthologs

Mouse Scrib: ENSMUSG00000022568

UniProt

Q14160

neXtProt

NX_Q14160

Human splice variants
Mouse splice variants

Protein structure