BS7581

antibody from Bioworld Technology, Inc
Targeting: SERPINB3 HsT1196, SCC, SCCA1, T4-A
Provider product page for BS7581
Western blot
Immunohistochemistry

Antibody data

Product number
BS7581 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SERPINB3 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human SERPINB3.
Description
SERPINB3 (Squamous Cell Carcinoma Antigen, SCCA1) is a member of the ov-serpins, a serine protease inhibitors family expressed in many cell types including normal epithelium, leukocytes, tumors of epithelial origin and primary liver cancer. Several studies, carried out in vitro and in vivo, have documented an important role of SERPINB3 in the modulation of programmed cell death by different mechanisms, both in inflammatory processes and in cancer. SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells. Mechanisms involved in apoptosis induction and regulation play a key role in the balance between cell proliferation and death. Imbalance of this equilibrium may contribute to the development of autoimmune diseases, as defective apoptosis of immune cells leads to deregulated autoreactive cell proliferation.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SERPINB3 protein structure - BS7581 shown in red.