Tissue expressionAmygdalaBasal gangliaCerebellumCerebral cortexChoroid plexusHippocampal formationHypothalamusMedulla oblongataMidbrainOlfactory bulbPonsSpinal cordThalamusWhite matterRetinaAdrenal glandParathyroid glandPituitary glandThyroid glandLungEsophagusSalivary glandTongueColonDuodenumRectumSmall intestineStomachGallbladderLiverPancreasKidneyUrinary bladderEpididymisProstateSeminal vesicleTestisBreastCervixEndometriumFallopian tubeOvaryPlacentaVaginaHeart muscleSkeletal muscleSmooth muscleAdipose tissueSkinAppendixBone marrowLymph nodeSpleenThymusTonsil02,0004,0006,0008,00010,00012,000
Cell line expressionAF22GAMGSH-SY5YU-138 MGU-251 MGU-87 MGHTCEpiHTERT-RPE1OE19CACO-2Hep G2CAPAN-2HEK 293NTERA-2RPTEC TERT1RT4PC-3SuSaA-431HaCaTSK-MEL-30WM-115A549HBEC3-KTSCLC-21HAN3-CABEWOEFO-21HeLaHTERT-HME1MCF7SiHaSK-BR-3T-47dHUVEC TERT2TIMEHSkMCASC diffASC TERT1BJBJ hTERT+BJ hTERT+ SV40 Large T+BJ hTERT+ SV40 Large T+ RasG12VFHDF/TERT166HBF TERT88HHSteCLHCN-M2RH-30U-2 OSU-2197DaudiHDLM-2HTEC/SVTERT24-BJURKATKarpas-707MOLT-4REHRPMI-8226U-266/70U-266/84U-698HAP1HELHL-60HMC-1K-562NB-4THP-1U-93705001,0001,5002,0002,5003,000
Protein structure

CSTB

Cystatin B
CST6, EPM1, PME, STFB 
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. [provided by RefSeq, Jul 2016]
More gene data

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                        874 antibodies from 39 providers.

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                        Proteintech Group
                        2 antibodies
                        Invitrogen Antibodies
                        45 antibodies
                        NSJ Bioreagents
                        7 antibodies
                        NovoPro Bioscience Inc.
                        1 antibody
                        OriGene
                        27 antibodies
                        Novus Biologicals
                        8 antibodies
                        R&D Systems
                        5 antibodies
                        Boster Biological Technology
                        6 antibodies
                        Atlas Antibodies
                        2 antibodies
                        Biorbyt
                        46 antibodies
                        Cusabio Biotech Co., Ltd
                        9 antibodies
                        Abbexa
                        13 antibodies
                        FineTest Biotech
                        1 antibody
                        antibodies-online
                        243 antibodies
                        Acris Antibodies GmbH
                        10 antibodies
                        Aviva Systems Biology
                        6 antibodies
                        Antibodies.com
                        13 antibodies
                        Abnova Corporation
                        11 antibodies
                        Affinity Biosciences
                        1 antibody
                        St John's Laboratory
                        5 antibodies
                        Bioworld Technology, Inc
                        1 antibody
                        Everest Biotech
                        1 antibody
                        Abcepta
                        9 antibodies
                        GeneTex
                        9 antibodies
                        Abbkine Scientific Co.Ltd.
                        2 antibodies
                        ProSci
                        5 antibodies
                        RabMAbs
                        4 antibodies
                        MilliporeSigma / Merck KGaA
                        6 antibodies
                        MyBioSource
                        17 antibodies
                        RayBiotech, Inc.
                        4 antibodies
                        Arigo
                        1 antibody
                        United States Biological
                        95 antibodies
                        Creative Biolabs
                        62 antibodies
                        Leading Biology
                        8 antibodies
                        Creative Diagnostics
                        6 antibodies
                        CPTAC
                        3 antibodies
                        MedChemExpress LLC
                        1 antibody