Ab175523

antibody from Aladdin Scientific Corporation

Targeting: RGMA RGM

ELISA (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Functional assay (Data presented on provider website)

Antibody Data

Product number

Ab175523

Provider

Aladdin Scientific Corporation

Product name

Elezanumab (anti-RGMA)

Antibody type

Recombinant

Description

Elezanumab (anti-RGMA) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab (anti-RGMA) potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab (anti-RGMA) promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. Elezanumab (anti-RGMA) has neuroregenerative and neuroprotective activities without impact on iron metabolism.

Reactivity

Human, Mouse, Rat

Conjugate

Unconjugated

Vial size

10mg,1mg,5mg

Concentration

Lot by Lot

Storage

Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.