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- Antigen structure
- References [14]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 16480-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16480-1-AP, RRID:AB_2150637
- Product name
- NDUFA4L2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NDUFA4L2 antibody (Cat. #16480-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NDUFA4L2 promotes trastuzumab resistance in HER2-positive breast cancer.
NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension.
Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force.
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
Mitochondrial NDUFA4L2 protein promotes the vitality of lung cancer cells by repressing oxidative stress.
Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma.
Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma.
Gene expression analyses reveal metabolic specifications in acute O2 -sensing chemoreceptor cells.
Single cell transcriptome analysis of mouse carotid body glomus cells.
Metabolic adaptation to chronic hypoxia in cardiac mitochondria.
Thyroid paraganglioma. Report of 3 cases and description of an immunohistochemical profile useful in the differential diagnosis with medullary thyroid carcinoma, based on complementary DNA array results.
Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.
Yuan Y, Gao H, Zhuang Y, Wei L, Yu J, Zhang Z, Zhang L, Wang L
Therapeutic advances in medical oncology 2021;13:17588359211027836
Therapeutic advances in medical oncology 2021;13:17588359211027836
NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension.
Liu Y, Nie X, Zhu J, Wang T, Li Y, Wang Q, Sun Z
Journal of cellular and molecular medicine 2021 Jan;25(2):1221-1237
Journal of cellular and molecular medicine 2021 Jan;25(2):1221-1237
Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force.
Liu Z, Chaillou T, Santos Alves E, Mader T, Jude B, Ferreira DMS, Hynynen H, Cheng AJ, Jonsson WO, Pironti G, Andersson DC, Kenne E, Ruas JL, Tavi P, Lanner JT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Dec;35(12):e22010
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Dec;35(12):e22010
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
Xu WN, Yang RZ, Zheng HL, Jiang LS, Jiang SD
Frontiers in cell and developmental biology 2020;8:515051
Frontiers in cell and developmental biology 2020;8:515051
Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
Moreno-Domínguez A, Ortega-Sáenz P, Gao L, Colinas O, García-Flores P, Bonilla-Henao V, Aragonés J, Hüttemann M, Grossman LI, Weissmann N, Sommer N, López-Barneo J
Science signaling 2020 Jan 21;13(615)
Science signaling 2020 Jan 21;13(615)
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
Xu WN, Zheng HL, Yang RZ, Liu T, Yu W, Zheng XF, Li B, Jiang SD, Jiang LS
Experimental & molecular medicine 2019 Nov 18;51(11):1-16
Experimental & molecular medicine 2019 Nov 18;51(11):1-16
Mitochondrial NDUFA4L2 protein promotes the vitality of lung cancer cells by repressing oxidative stress.
Meng L, Yang X, Xie X, Wang M
Thoracic cancer 2019 Apr;10(4):676-685
Thoracic cancer 2019 Apr;10(4):676-685
Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma.
Nagao K, Shinohara N, Smit F, de Weijert M, Jannink S, Owada Y, Mulders P, Oosterwijk E, Matsuyama H
BMC cancer 2018 Nov 15;18(1):1114
BMC cancer 2018 Nov 15;18(1):1114
Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma.
Lucarelli G, Rutigliano M, Sallustio F, Ribatti D, Giglio A, Lepore Signorile M, Grossi V, Sanese P, Napoli A, Maiorano E, Bianchi C, Perego RA, Ferro M, Ranieri E, Serino G, Bell LN, Ditonno P, Simone C, Battaglia M
Aging 2018 Dec 11;10(12):3957-3985
Aging 2018 Dec 11;10(12):3957-3985
Gene expression analyses reveal metabolic specifications in acute O2 -sensing chemoreceptor cells.
Gao L, Bonilla-Henao V, García-Flores P, Arias-Mayenco I, Ortega-Sáenz P, López-Barneo J
The Journal of physiology 2017 Sep 15;595(18):6091-6120
The Journal of physiology 2017 Sep 15;595(18):6091-6120
Single cell transcriptome analysis of mouse carotid body glomus cells.
Zhou T, Chien MS, Kaleem S, Matsunami H
The Journal of physiology 2016 Aug 1;594(15):4225-51
The Journal of physiology 2016 Aug 1;594(15):4225-51
Metabolic adaptation to chronic hypoxia in cardiac mitochondria.
Heather LC, Cole MA, Tan JJ, Ambrose LJ, Pope S, Abd-Jamil AH, Carter EE, Dodd MS, Yeoh KK, Schofield CJ, Clarke K
Basic research in cardiology 2012 May;107(3):268
Basic research in cardiology 2012 May;107(3):268
Thyroid paraganglioma. Report of 3 cases and description of an immunohistochemical profile useful in the differential diagnosis with medullary thyroid carcinoma, based on complementary DNA array results.
Castelblanco E, Gallel P, Ros S, Gatius S, Valls J, De-Cubas AA, Maliszewska A, Yebra-Pimentel MT, Menarguez J, Gamallo C, Opocher G, Robledo M, Matias-Guiu X
Human pathology 2012 Jul;43(7):1103-12
Human pathology 2012 Jul;43(7):1103-12
Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity.
Tello D, Balsa E, Acosta-Iborra B, Fuertes-Yebra E, Elorza A, Ordóñez Á, Corral-Escariz M, Soro I, López-Bernardo E, Perales-Clemente E, Martínez-Ruiz A, Enríquez JA, Aragonés J, Cadenas S, Landázuri MO
Cell metabolism 2011 Dec 7;14(6):768-79
Cell metabolism 2011 Dec 7;14(6):768-79
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 16480-1-AP(NDUFA4L2 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using NDUFA4L2 antibody 16480-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 16480-1-AP(NDUFA4L2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 16480-1-AP(NDUFA4L2 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
