Tissue expression
Cell line expression
Protein structure
PTP4A2
Protein tyrosine phosphatase 4A2HU-PP-1, OV-1, PRL-2, PRL2, ptp-IV1a, PTP4A, PTPCAAX2
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Top validated antibodies |
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Abgent | AP6838c | Polyclonal |
WB
ICC
IHC
FC |
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NSJ Bioreagents | F54431 | Polyclonal |
WB
ICC
IHC
FC |
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GeneTex | GTX81695 | Polyclonal |
WB
ICC
IHC
FC |
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Novus Biologicals | NBP2-30075 | Polyclonal |
WB
ICC
IHC
FC |
||
OriGene | TA324871 | Polyclonal |
WB
ICC
IHC
FC |
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Supportive data in Antibodypedia
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Recommended by provider