APR03855G

antibody from Leading Biology

Targeting: CTTN EMS1

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APR03855G

Provider

Leading Biology

Product name

CTTN Antibody (Center)

Antibody type

Polyclonal

Description

This gene is overexpressed in breast cancer and squamouscell carcinomas of the head and neck. The encoded protein islocalized in the cytoplasm and in areas of the cell-substratumcontacts. This gene has two roles: (1) regulating the interactionsbetween components of adherens-type junctions and (2) organizingthe cytoskeleton and cell adhesion structures of epithelia andcarcinoma cells. During apoptosis, the encoded protein is degradedin a caspase-dependent manner. The aberrant regulation of this genecontributes to tumor cell invasion and metastasis. Three splicevariants that encode different isoforms have been identified forthis gene.

Reactivity

Human

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.