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Immunocytochemistry
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 306402 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#306402, RRID:AB_314600
- Product name
- Purified anti-human CD178 (Fas-L)
- Antibody type
- Monoclonal
- Antigen
- L5178Y mouse T lymphoma cells expressing recombinant human FasL
- Description
- CD178 is a 38-42 kD type II glycoprotein also known as Fas ligand and CD95L. CD178 belongs to the TNF superfamily and is expressed on activated T lymphocytes, NK cells, monocytes, and granulocytes. CD178 is also expressed on parenchymal cells of the retina and cornea, retinal pigment epithelial cells, and testis. The extracellular region of FasL can be cleaved by matrix metalloproteinases (MMPs) to give rise to a 26 kD soluble protein. CD178 binds to CD95, a member of the TNFR superfamily, to induce apoptosis. CD95/CD95L interactions play an important role in the maintenance of peripheral tolerance and survival.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Efficient Nef-mediated downmodulation of TCR-CD3 and CD28 is associated with high CD4+ T cell counts in viremic HIV-2 infection.
Phenotypic and functional characterization of human γδ T-cell subsets in response to influenza A viruses.
Intensive resistance exercise induces lymphocyte apoptosis via cortisol and glucocorticoid receptor-dependent pathways.
Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells.
Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis.
Khalid M, Yu H, Sauter D, Usmani SM, Schmokel J, Feldman J, Gruters RA, van der Ende ME, Geyer M, Rowland-Jones S, Osterhaus AD, Kirchhoff F
Journal of virology 2012 May;86(9):4906-20
Journal of virology 2012 May;86(9):4906-20
Phenotypic and functional characterization of human γδ T-cell subsets in response to influenza A viruses.
Qin G, Liu Y, Zheng J, Xiang Z, Ng IH, Malik Peiris JS, Lau YL, Tu W
The Journal of infectious diseases 2012 Jun;205(11):1646-53
The Journal of infectious diseases 2012 Jun;205(11):1646-53
Intensive resistance exercise induces lymphocyte apoptosis via cortisol and glucocorticoid receptor-dependent pathways.
Krüger K, Agnischock S, Lechtermann A, Tiwari S, Mishra M, Pilat C, Wagner A, Tweddell C, Gramlich I, Mooren FC
Journal of applied physiology (Bethesda, Md. : 1985) 2011 May;110(5):1226-32
Journal of applied physiology (Bethesda, Md. : 1985) 2011 May;110(5):1226-32
Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells.
Li JH, D'Alessio A, Pober JS
The American journal of pathology 2009 Sep;175(3):1124-35
The American journal of pathology 2009 Sep;175(3):1124-35
Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis.
Strauss L, Bergmann C, Whiteside TL
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 1;182(3):1469-80
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 1;182(3):1469-80
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human Fas Ligand transfected cells stained with purified NOK-1, followed by biotinylated anti-mouse IgG and Sav-PE
- Conjugate
- Unconjugated
