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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 16661-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16661-1-AP, RRID:AB_2214249
- Product name
- UGT2B7 antibody
- Antibody type
- Polyclonal
- Description
- UGT2B7 antibody (Cat. #16661-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, pig and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression.
Network Pharmacology-Based Prediction and Verification of Qingluo Tongbi Formula to Reduce Liver Toxicity of Tripterygium wilfordii via UGT2B7 in Endoplasmic Reticulum.
Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Investigation of the Endoplasmic Reticulum Localization of UDP-Glucuronosyltransferase 2B7 with Systematic Deletion Mutants.
Quantitative proteomics by SWATH-MS reveals sophisticated metabolic reprogramming in hepatocellular carcinoma tissues.
Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing.
Inter-isoform Hetero-dimerization of Human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A9, and 2B7 and Impacts on Glucuronidation Activity.
A Rare UGT2B7 Variant Creates a Novel N-Glycosylation Site at Codon 121 with Impaired Enzyme Activity.
Homo- and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity.
Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications.
Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells.
Miyauchi Y, Tanaka Y, Nagata K, Yamazoe Y, Mackenzie PI, Yamada H, Ishii Y
British journal of pharmacology 2020 Mar;177(5):1077-1089
British journal of pharmacology 2020 Mar;177(5):1077-1089
Network Pharmacology-Based Prediction and Verification of Qingluo Tongbi Formula to Reduce Liver Toxicity of Tripterygium wilfordii via UGT2B7 in Endoplasmic Reticulum.
Li M, Wang J, Fu L, Lu Y, Xu J, Zhou L, Zhu H, Fang L, Feng Z, Xie T, Zhou X
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 15;26:e920376
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 15;26:e920376
Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Miyauchi Y, Kurita A, Yamashita R, Takamatsu T, Ikushiro S, Mackenzie PI, Tanaka Y, Ishii Y
Biochemical and biophysical research communications 2020 Apr 30;525(2):348-353
Biochemical and biophysical research communications 2020 Apr 30;525(2):348-353
Investigation of the Endoplasmic Reticulum Localization of UDP-Glucuronosyltransferase 2B7 with Systematic Deletion Mutants.
Miyauchi Y, Kimura S, Kimura A, Kurohara K, Hirota Y, Fujimoto K, Mackenzie PI, Tanaka Y, Ishii Y
Molecular pharmacology 2019 May;95(5):551-562
Molecular pharmacology 2019 May;95(5):551-562
Quantitative proteomics by SWATH-MS reveals sophisticated metabolic reprogramming in hepatocellular carcinoma tissues.
Gao Y, Wang X, Sang Z, Li Z, Liu F, Mao J, Yan D, Zhao Y, Wang H, Li P, Ying X, Zhang X, He K, Wang H
Scientific reports 2017 Apr 5;7:45913
Scientific reports 2017 Apr 5;7:45913
Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing.
Rouleau M, Tourancheau A, Girard-Bock C, Villeneuve L, Vaucher J, Duperré AM, Audet-Delage Y, Gilbert I, Popa I, Droit A, Guillemette C
Cell reports 2016 Sep 27;17(1):114-124
Cell reports 2016 Sep 27;17(1):114-124
Inter-isoform Hetero-dimerization of Human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A9, and 2B7 and Impacts on Glucuronidation Activity.
Yuan LM, Gao ZZ, Sun HY, Qian SN, Xiao YS, Sun LL, Zeng S
Scientific reports 2016 Nov 18;6:34450
Scientific reports 2016 Nov 18;6:34450
A Rare UGT2B7 Variant Creates a Novel N-Glycosylation Site at Codon 121 with Impaired Enzyme Activity.
Girard-Bock C, Benoit-Biancamano MO, Villeneuve L, Desjardins S, Guillemette C
Drug metabolism and disposition: the biological fate of chemicals 2016 Dec;44(12):1867-1871
Drug metabolism and disposition: the biological fate of chemicals 2016 Dec;44(12):1867-1871
Homo- and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity.
Yuan L, Qian S, Xiao Y, Sun H, Zeng S
Biochemical pharmacology 2015 May 1;95(1):58-70
Biochemical pharmacology 2015 May 1;95(1):58-70
Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications.
Shu XH, Wang LL, Li H, Song X, Shi S, Gu JY, Wu ML, Chen XY, Kong QY, Liu J
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2015 Apr;12(2):491-501
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2015 Apr;12(2):491-501
Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells.
Sun Z, Shi S, Li H, Shu XH, Chen XY, Kong QY, Liu J
Cancer chemotherapy and pharmacology 2013 Nov;72(5):965-73
Cancer chemotherapy and pharmacology 2013 Nov;72(5):965-73
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 16661-1-AP(UGT2B7 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using UGT2B7 antibody 16661-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 16661-1-AP(UGT2B7 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 16661-1-AP(UGT2B7 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
