PACS1

This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]

Description

Phosphofurin acidic cluster sorting protein 1

Tissue specificity

Low tissue specificity

Subcell location

Microtubules, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (66070272 - 66244744)

Ensembl ID

ENSG00000175115  (ver. 103.38)

Orthologs

Mouse Pacs1: ENSMUSG00000024855

UniProt

Q6VY07

neXtProt

NX_Q6VY07

Human splice variants
Mouse splice variants

Protein structure