Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations [0]
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- Product number
- ABIN1001821 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) antibody
- Antibody type
- Polyclonal
- Antigen
- ARF-BP1 antibody was raised in rabbits against a 19 amino acid peptide from near the carboxy terminus of human ARF-BP1.
- Description
- Affinity chromatography purified via peptide column.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 μg
- Storage
- 4°C
- Handling
- Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container?s cap.
Submitted references The ARF tumour suppressor.
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
Gallagher SJ, Kefford RF, Rizos H
The international journal of biochemistry & cell biology 2006;38(10):1637-41
The international journal of biochemistry & cell biology 2006;38(10):1637-41
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.
Zhong Q, Gao W, Du F, Wang X
Cell 2005 Jul 1;121(7):1085-95
Cell 2005 Jul 1;121(7):1085-95
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.
Chen D, Kon N, Li M, Zhang W, Qin J, Gu W
Cell 2005 Jul 1;121(7):1071-83
Cell 2005 Jul 1;121(7):1071-83
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
Zhang Y, Xiong Y, Yarbrough WG
Cell 1998 Mar 20;92(6):725-34
Cell 1998 Mar 20;92(6):725-34
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