CABT-B1604

antibody from Creative Diagnostics

Targeting: SLC39A8 BIGM103

Western blot (Recommended by provider)

Antibody Data

Product number

CABT-B1604

Provider

Creative Diagnostics

Product name

Anti-SLC39A8 polyclonal antibody

Antibody type

Polyclonal

Description

Zinc transporter ZIP8 is encoded by the SLC39A8 (also known as BIGM103, ZIP8, PP3105) gene (Gene ID 64116) in human. Zinc transporters mediate the transport of zinc ions into intracellular compartments as well as the export of excess zinc out of cells. Disruption of zinc homeostasis is responsible for many chronic neurodegenerative diseases and acute neural injuries. Excessive and inadequate levels of bioavailable zinc are detrimental to the health of neurons. Two classes of multipass transmembrane Zn transporters are known, including 10 ZnTs and 14 ZIPs, that exhibit opposing functions in mediating zinc homeostasis. These transporters are located on plasma and vesicular membranes with tissue-specific expression pattern. ZIP8 is a negative regulator of the NF-°ÙB signaling pathway through zinc-mediated suppression of IKK activity in monocytes, macrophages, and lung epithelia. ZIP8 expression is induced following innate immune activation and correlates with intracellular zinc sequestration. Human ZIP8 is an 8-transmembrane protein (a.a. 9-29, 133-153, 161-181, 192-212, 303-323, 366-386, 389-409, 430-450) that has both its N- and C-termini (a.a. 1-8 & 451-460) exposed extracelluarly with 4 intracellular and 3 extracellular loops in between.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 _g

Concentration

Please refer to lot specific datasheet.

Storage

Stable for 1 year at 2-8°C from date of receipt.