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- Antibody Data
- Antigen structure
- References [36]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
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- Product number
- 21207-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21207-1-AP, RRID:AB_10734584
- Product name
- TET2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TET2 antibody (Cat. #21207-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references MgFe-LDH Nanoparticles: A Promising Leukemia Inhibitory Factor Replacement for Self-Renewal and Pluripotency Maintenance in Cultured Mouse Embryonic Stem Cells.
Loss of ten-eleven translocation 2 induces cardiac hypertrophy and fibrosis through modulating ERK signaling pathway.
DNA demethylase Tet2 suppresses cisplatin-induced acute kidney injury.
The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins.
Inhibition of NF-κB is required for oleanolic acid to downregulate PD-L1 by promoting DNA demethylation in gastric cancer cells.
Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway.
Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and it is modified by oteocalcin administration in mice.
Experimental eye research / short communication format characterization of DNA hydroxymethylation in the ocular choroid.
Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro.
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Proteases Activate Pregnancy Neutrophils by a Protease-Activated Receptor 1 Pathway: Epigenetic Implications for Preeclampsia.
Restoration of TET2 deficiency inhibits tumor growth in head neck squamous cell carcinoma.
Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice.
TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.
Reduction of Tet2 exacerbates early stage Alzheimer's pathology and cognitive impairments in 2×Tg-AD mice.
Protease Amplification of the Inflammatory Response Induced by Commensal Bacteria: Implications for Racial Disparity in Term and Preterm Birth.
Demethylation of HACE1 gene promoter by propofol promotes autophagy of human A549 cells.
Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation.
Aanat Knockdown and Melatonin Supplementation in Embryo Development: Involvement of Mitochondrial Function and DNA Methylation.
TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.
Pregnancy-Induced Physiologic Adaptation of the Abdominal Aorta Is Associated with Changes in Gene Expression and Genomic Methylation.
Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation.
Ten-eleven translocation 2 demethylates the MMP9 promoter, and its down-regulation in preeclampsia impairs trophoblast migration and invasion.
Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.
The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation.
TET2 facilitates PPARγ agonist-mediated gene regulation and insulin sensitization in adipocytes.
TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System.
Epigenetic modification differences between fetal fibroblast cells and mesenchymal stem cells of the Arbas Cashmere goat.
Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus.
Restricted TET2 Expression in Germinal Center Type B Cells Promotes Stringent Epstein-Barr Virus Latency.
A role for TET2 in parathyroid carcinoma.
Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells.
A Novel Function of TET2 in CNS: Sustaining Neuronal Survival.
Oxidized low-density lipoprotein inhibits THP-1-derived macrophage autophagy via TET2 down-regulation.
Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.
TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
He X, Zhu Y, Yang L, Wang Z, Wang Z, Feng J, Wen X, Cheng L, Zhu R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(9):2003535
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(9):2003535
Loss of ten-eleven translocation 2 induces cardiac hypertrophy and fibrosis through modulating ERK signaling pathway.
Tao H, Xu W, Qu W, Gao H, Zhang J, Cheng X, Liu N, Chen J, Xu GL, Li X, Shu Q
Human molecular genetics 2021 May 29;30(10):865-879
Human molecular genetics 2021 May 29;30(10):865-879
DNA demethylase Tet2 suppresses cisplatin-induced acute kidney injury.
Bao Y, Bai M, Zhu H, Yuan Y, Wang Y, Zhang Y, Wang J, Xie X, Yao X, Mao J, Fu X, Chen J, Yang Y, Lin W
Cell death discovery 2021 Jun 17;7(1):167
Cell death discovery 2021 Jun 17;7(1):167
The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins.
Huang Z, Yu J, Cui W, Johnson BK, Kim K, Pfeifer GP
Science advances 2021 Jan;7(4)
Science advances 2021 Jan;7(4)
Inhibition of NF-κB is required for oleanolic acid to downregulate PD-L1 by promoting DNA demethylation in gastric cancer cells.
Lu X, Li Y, Yang W, Tao M, Dai Y, Xu J, Xu Q
Journal of biochemical and molecular toxicology 2021 Jan;35(1):e22621
Journal of biochemical and molecular toxicology 2021 Jan;35(1):e22621
Low shear stress induced vascular endothelial cell pyroptosis by TET2/SDHB/ROS pathway.
Chen J, Zhang J, Wu J, Zhang S, Liang Y, Zhou B, Wu P, Wei D
Free radical biology & medicine 2021 Jan;162:582-591
Free radical biology & medicine 2021 Jan;162:582-591
Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and it is modified by oteocalcin administration in mice.
Kawakubo-Yasukochi T, Yano E, Kimura S, Nishinakagawa T, Mizokami A, Hayashi Y, Hatakeyama Y, Ohe K, Yasukochi A, Nakamura S, Jimi E, Hirata M
Molecular metabolism 2021 Dec;54:101360
Molecular metabolism 2021 Dec;54:101360
Experimental eye research / short communication format characterization of DNA hydroxymethylation in the ocular choroid.
Pomerleau J, Weidmann C, Coutant K, Lowry CM, Veilleux MP, Bérubé J, Wagner JR, Landreville S
Experimental eye research 2021 Apr;205:108473
Experimental eye research 2021 Apr;205:108473
Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro.
Li T, Fang T, Xu L, Liu X, Li X, Xue M, Yu X, Sun B, Chen L
Frontiers in pharmacology 2020;11:622153
Frontiers in pharmacology 2020;11:622153
Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.
Sivalingam K, Samikkannu T
Brain sciences 2020 Sep 5;10(9)
Brain sciences 2020 Sep 5;10(9)
Proteases Activate Pregnancy Neutrophils by a Protease-Activated Receptor 1 Pathway: Epigenetic Implications for Preeclampsia.
Walsh SW, Nugent WH, Al Dulaimi M, Washington SL, Dacha P, Strauss JF 3rd
Reproductive sciences (Thousand Oaks, Calif.) 2020 Nov;27(11):2115-2127
Reproductive sciences (Thousand Oaks, Calif.) 2020 Nov;27(11):2115-2127
Restoration of TET2 deficiency inhibits tumor growth in head neck squamous cell carcinoma.
Huang R, Wang Y, Ge H, Wang D, Wang Y, Zhang W, Yang J, Cheng J
Annals of translational medicine 2020 Mar;8(6):329
Annals of translational medicine 2020 Mar;8(6):329
Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice.
Buck JM, O'Neill HC, Stitzel JA
Epigenetics & chromatin 2020 Mar 5;13(1):13
Epigenetics & chromatin 2020 Mar 5;13(1):13
TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.
Morin A, Goncalves J, Moog S, Castro-Vega LJ, Job S, Buffet A, Fontenille MJ, Woszczyk J, Gimenez-Roqueplo AP, Letouzé E, Favier J
Cell reports 2020 Mar 31;30(13):4551-4566.e7
Cell reports 2020 Mar 31;30(13):4551-4566.e7
Reduction of Tet2 exacerbates early stage Alzheimer's pathology and cognitive impairments in 2×Tg-AD mice.
Li L, Qiu Y, Miao M, Liu Z, Li W, Zhu Y, Wang Q
Human molecular genetics 2020 Jul 21;29(11):1833-1852
Human molecular genetics 2020 Jul 21;29(11):1833-1852
Protease Amplification of the Inflammatory Response Induced by Commensal Bacteria: Implications for Racial Disparity in Term and Preterm Birth.
Walsh SW, Nugent WH, Alam SMK, Washington SL, Teves M, Jefferson KK, Strauss JF 3rd
Reproductive sciences (Thousand Oaks, Calif.) 2020 Jan;27(1):246-259
Reproductive sciences (Thousand Oaks, Calif.) 2020 Jan;27(1):246-259
Demethylation of HACE1 gene promoter by propofol promotes autophagy of human A549 cells.
Li S, Yang H, Zhao M, Gong L, Wang Y, Lv Z, Quan Y, Wang Z
Oncology letters 2020 Dec;20(6):280
Oncology letters 2020 Dec;20(6):280
Reprogramming of DNA methylation at NEUROD2-bound sequences during cortical neuron differentiation.
Hahn MA, Jin SG, Li AX, Liu J, Huang Z, Wu X, Kim BW, Johnson J, Bilbao AV, Tao S, Yim JA, Fong Y, Goebbels S, Schwab MH, Lu Q, Pfeifer GP
Science advances 2019 Oct;5(10):eaax0080
Science advances 2019 Oct;5(10):eaax0080
Aanat Knockdown and Melatonin Supplementation in Embryo Development: Involvement of Mitochondrial Function and DNA Methylation.
Yang M, Tao J, Wu H, Guan S, Liu L, Zhang L, Deng S, He C, Ji P, Liu J, Liu G
Antioxidants & redox signaling 2019 Jun 20;30(18):2050-2065
Antioxidants & redox signaling 2019 Jun 20;30(18):2050-2065
TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.
Sun X, Cui Y, Feng H, Liu H, Liu X
The Journal of experimental medicine 2019 Dec 2;216(12):2819-2837
The Journal of experimental medicine 2019 Dec 2;216(12):2819-2837
Pregnancy-Induced Physiologic Adaptation of the Abdominal Aorta Is Associated with Changes in Gene Expression and Genomic Methylation.
Gelinne A, Brown L, Ko NL, Osol G, Brown S
Journal of vascular research 2018;55(5):319-327
Journal of vascular research 2018;55(5):319-327
Hypermethylation of the Micro-RNA 145 Promoter Is the Key Regulator for NLRP3 Inflammasome-Induced Activation and Plaque Formation.
Zhong W, Li B, Xu Y, Yang P, Chen R, Wang Z, Shao C, Song J, Yan J
JACC. Basic to translational science 2018 Oct;3(5):604-624
JACC. Basic to translational science 2018 Oct;3(5):604-624
Ten-eleven translocation 2 demethylates the MMP9 promoter, and its down-regulation in preeclampsia impairs trophoblast migration and invasion.
Li X, Wu C, Shen Y, Wang K, Tang L, Zhou M, Yang M, Pan T, Liu X, Xu W
The Journal of biological chemistry 2018 Jun 29;293(26):10059-10070
The Journal of biological chemistry 2018 Jun 29;293(26):10059-10070
Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.
Barazeghi E, Prabhawa S, Norlén O, Hellman P, Stålberg P, Westin G
BMC cancer 2018 Jul 25;18(1):764
BMC cancer 2018 Jul 25;18(1):764
The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation.
Zhang J, Cao H, Xie J, Fan C, Xie Y, He X, Liao M, Zhang S, Wang H
Cell death & disease 2018 Feb 14;9(2):224
Cell death & disease 2018 Feb 14;9(2):224
TET2 facilitates PPARγ agonist-mediated gene regulation and insulin sensitization in adipocytes.
Bian F, Ma X, Villivalam SD, You D, Choy LR, Paladugu A, Fung S, Kang S
Metabolism: clinical and experimental 2018 Dec;89:39-47
Metabolism: clinical and experimental 2018 Dec;89:39-47
TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System.
Peng J, Tang ZH, Ren Z, He B, Zeng Y, Liu LS, Wang Z, Wei DH, Zheng XL, Jiang ZS
Frontiers in pharmacology 2017;8:486
Frontiers in pharmacology 2017;8:486
Epigenetic modification differences between fetal fibroblast cells and mesenchymal stem cells of the Arbas Cashmere goat.
Wang X, Wang Z, Wang Q, Wang H, Liang H, Liu D
Research in veterinary science 2017 Oct;114:363-369
Research in veterinary science 2017 Oct;114:363-369
Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus.
Lu F, Wiedmer A, Martin KA, Wickramasinghe PJMS, Kossenkov AV, Lieberman PM
Journal of virology 2017 Oct 15;91(20)
Journal of virology 2017 Oct 15;91(20)
Restricted TET2 Expression in Germinal Center Type B Cells Promotes Stringent Epstein-Barr Virus Latency.
Wille CK, Li Y, Rui L, Johannsen EC, Kenney SC
Journal of virology 2017 Mar 1;91(5)
Journal of virology 2017 Mar 1;91(5)
A role for TET2 in parathyroid carcinoma.
Barazeghi E, Gill AJ, Sidhu S, Norlén O, Dina R, Palazzo FF, Hellman P, Stålberg P, Westin G
Endocrine-related cancer 2017 Jul;24(7):329-338
Endocrine-related cancer 2017 Jul;24(7):329-338
Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells.
Gao J, Ma Y, Fu HL, Luo Q, Wang Z, Xiao YH, Yang H, Cui DX, Jin WL
Protein & cell 2016 May;7(5):351-61
Protein & cell 2016 May;7(5):351-61
A Novel Function of TET2 in CNS: Sustaining Neuronal Survival.
Mi Y, Gao X, Dai J, Ma Y, Xu L, Jin W
International journal of molecular sciences 2015 Sep 10;16(9):21846-57
International journal of molecular sciences 2015 Sep 10;16(9):21846-57
Oxidized low-density lipoprotein inhibits THP-1-derived macrophage autophagy via TET2 down-regulation.
Li G, Peng J, Liu Y, Li X, Yang Q, Li Y, Tang Z, Wang Z, Jiang Z, Wei D
Lipids 2015 Feb;50(2):177-83
Lipids 2015 Feb;50(2):177-83
Dynamics of ten-eleven translocation hydroxylase family proteins and 5-hydroxymethylcytosine in oligodendrocyte differentiation.
Zhao X, Dai J, Ma Y, Mi Y, Cui D, Ju G, Macklin WB, Jin W
Glia 2014 Jun;62(6):914-26
Glia 2014 Jun;62(6):914-26
TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
Fu HL, Ma Y, Lu LG, Hou P, Li BJ, Jin WL, Cui DX
Journal of biomedical nanotechnology 2014 Jul;10(7):1217-30
Journal of biomedical nanotechnology 2014 Jul;10(7):1217-30
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 21207-1-AP(TET2 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TET2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TET2. This antibody recognizes human, mouse antigen. The TET2 antibody has been validated for the following applications: ELISA, WB, IP analysis.
