352501

antibody from BioLegend

Targeting: LRRC32 D11S833E, GARP

Antibody data

Submit

Validation data

Product number: 352501 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#352501, RRID:AB_10897452
Product name: Purified anti-human GARP (LRRC32)
Antibody type: Monoclonal
Antigen: LRRC32-DNA vaccination
Description: Glycoprotein A Repetitions Predominant (GARP), also known as leucine rich repeat containing 32 (LRC32), is a 80 kD type I membrane glycoprotein with 20 leucine rich repeats in the extracellular portion of the protein. GARP was found on the surface of megakaryocytes, platelets, and activated Tregs (CD4+, CD25+, FoxP3+ cells) and serves as a receptor for latent TGF-β. Recent evidence suggests that GARP may play a role in controlling suppressor function of Tregs. A mutation in GARP has been reported in a large Samaritan kindred with Usher syndrome type 1, an autosomal recessive disease characterized by profound congenital sensorineural deafness, vestibular dysfunction, and progressive visual loss. In addition, it has been found that GARP mRNA is highly amplified in different tumors, which indicates that tumor cells may use GARP to express TGF-β or to capture TGF-β from their surroundings, resulting in local suppression of anti-tumor immune responses or the induction of Tregs.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 25 µg
Concentration: 0.5 mg/ml
Storage: The antibody solution should be stored undiluted at 4°C.

LRRC32 protein structure - 352501 shown in red.