Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60770 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- SLC4A7 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human SLC4A7.
- Description
- SLC4A7 (solute carrier family 4 member 7), also known as sodium bicarbonate cotransporter 3, is a 1,214 amino acid multi-pass membrane protein that mediates the movement of sodium and bicarbonate across the cell membrane. Studies in mice have shown that hydrogen ion disposal mediated by SLC4A7 is essential for auditory and visual systems, therefore, defects in the gene encoding SLC4A7 may result in the human manifestation of Usher syndrome, a leading cause of deafblindness. With highest expression in spleen and testis, SLC4A7 is also expressed in a variety of other tissues, including brain, skeletal muscle and heart. Due to its critical role in intracellular pH regulation, SLC4A7 is notably affected by hypoxic states during which protein levels are decreased, presumably for reduction of energy consumption. There are five isoforms of SLC4A7 that exist as a result of alternative splicing events.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of SLC4A7 pAb at 1:500 dilutionLane1:A549 whole cell lysateLane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate