Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [3]
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN136329 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Breast Cancer 1 (BRCA1) antibody
- Antibody type
- Monoclonal
- Antigen
- Protein fragment expressed in E. coli corresponding to amino acids 762-1315.
- Description
- Protein G affinity purified
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1 mg/ml
Submitted references BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest.
Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.
BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite.
Tumor suppressor p53 is required to modulate BRCA1 expression.
Transactivation of the p21 promoter by BRCA1 splice variants in mammary epithelial cells: evidence for both common and distinct activities of wildtype and mutant forms.
Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.
Reduction of BRCA1 protein expression in Japanese sporadic breast carcinomas and its frequent loss in BRCA1-associated cases.
Biological functions of the BRCA1 protein.
BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.
Aberrant subcellular localization of BRCA1 in breast cancer.
Ongusaha PP, Ouchi T, Kim KT, Nytko E, Kwak JC, Duda RB, Deng CX, Lee SW
Oncogene 2003 Jun 12;22(24):3749-58
Oncogene 2003 Jun 12;22(24):3749-58
Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.
Zhong Q, Boyer TG, Chen PL, Lee WH
Cancer research 2002 Jul 15;62(14):3966-70
Cancer research 2002 Jul 15;62(14):3966-70
BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite.
Bernard-Gallon DJ, Déchelotte P, Vissac C, Aunoble B, Cravello L, Malpuech G, Bignon YJ
Breast cancer research : BCR 2001;3(1):61-5
Breast cancer research : BCR 2001;3(1):61-5
Tumor suppressor p53 is required to modulate BRCA1 expression.
Arizti P, Fang L, Park I, Yin Y, Solomon E, Ouchi T, Aaronson SA, Lee SW
Molecular and cellular biology 2000 Oct;20(20):7450-9
Molecular and cellular biology 2000 Oct;20(20):7450-9
Transactivation of the p21 promoter by BRCA1 splice variants in mammary epithelial cells: evidence for both common and distinct activities of wildtype and mutant forms.
Lu M, Arrick BA
Oncogene 2000 Dec 14;19(54):6351-60
Oncogene 2000 Dec 14;19(54):6351-60
Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells.
Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM, Avraham H
The Journal of biological chemistry 1999 Nov 5;274(45):32274-8
The Journal of biological chemistry 1999 Nov 5;274(45):32274-8
Reduction of BRCA1 protein expression in Japanese sporadic breast carcinomas and its frequent loss in BRCA1-associated cases.
Yoshikawa K, Honda K, Inamoto T, Shinohara H, Yamauchi A, Suga K, Okuyama T, Shimada T, Kodama H, Noguchi S, Gazdar AF, Yamaoka Y, Takahashi R
Clinical cancer research : an official journal of the American Association for Cancer Research 1999 Jun;5(6):1249-61
Clinical cancer research : an official journal of the American Association for Cancer Research 1999 Jun;5(6):1249-61
Biological functions of the BRCA1 protein.
Lee WH, Chew HK, Farmer AA, Chen PL
Breast disease 1998 Apr;10(1-2):11-22
Breast disease 1998 Apr;10(1-2):11-22
BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner.
Chen Y, Farmer AA, Chen CF, Jones DC, Chen PL, Lee WH
Cancer research 1996 Jul 15;56(14):3168-72
Cancer research 1996 Jul 15;56(14):3168-72
Aberrant subcellular localization of BRCA1 in breast cancer.
Chen Y, Chen CF, Riley DJ, Allred DC, Chen PL, Von Hoff D, Osborne CK, Lee WH
Science (New York, N.Y.) 1995 Nov 3;270(5237):789-91
Science (New York, N.Y.) 1995 Nov 3;270(5237):789-91
No comments: Submit comment
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Image(s): Western Blotting
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Image(s): Western Blotting
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Image(s): Western Blotting
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Image(s): Flow cytometry
