Tissue expression
Cell line expression
Protein structure
ATRX
ATRX chromatin remodelerJMS, MRX52, RAD54, XH2, XNP
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
Top validated antibodies |
|||||
Atlas Antibodies | HPA001906 | 15 references | Polyclonal |
WB
ICC
IHC
|
|
GeneTex | GTX101310 | 2 references | Polyclonal |
WB
ICC
IP
IHC |
|
antibodies-online | ABIN442805 | 2 references | Polyclonal |
WB
ICC
IP
IHC |
|
Novus Biologicals | NBP1-32851 | 2 references | Polyclonal |
WB
ICC
IP
IHC |
|
Invitrogen Antibodies | PA5-21348 | 1 references | Polyclonal |
WB
ICC
IHC
OA |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider