Tissue expression
Cell line expression
Protein structure
PRR5
Proline rich 5FLJ20185k, PP610, Protor-1
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]
Top validated antibodies |
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Proteintech Group | 17948-1-AP | 1 references | Polyclonal |
WB
EL
ICC
IP
IHC
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Invitrogen Antibodies | 17948-1-AP | Polyclonal |
WB
ICC
IP
IHC
OA
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NovoPro Bioscience Inc. | 114276 | Polyclonal |
WB
EL
ICC
IP
IHC
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FineTest Biotech | FNab06830 | Polyclonal |
WB
EL
ICC
IP
IHC
|
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GeneTex | GTX31436 | Polyclonal |
WB
EL
ICC
IHC |
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