Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 15128-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15128-1-AP, RRID:AB_2267290
- Product name
- NHP2 antibody
- Antibody type
- Polyclonal
- Description
- NHP2 antibody (Cat. #15128-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Nhp2 is a reader of H2AQ105me and part of a network integrating metabolism with rRNA synthesis.
Structure of human telomerase holoenzyme with bound telomeric DNA.
SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization.
NHP2 downregulation counteracts hTR-mediated activation of the DNA damage response at ALT telomeres.
N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation.
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
Differential requirements for H/ACA ribonucleoprotein components in cell proliferation and response to DNA damage.
Expressional analysis of NOLA1, NOLA2, NOLA3 and DKC1, the core proteins in H/ACA riboproteins, in gastric and colorectal cancers.
Mawer JSP, Massen J, Reichert C, Grabenhorst N, Mylonas C, Tessarz P
EMBO reports 2021 Oct 5;22(10):e52435
EMBO reports 2021 Oct 5;22(10):e52435
Structure of human telomerase holoenzyme with bound telomeric DNA.
Ghanim GE, Fountain AJ, van Roon AM, Rangan R, Das R, Collins K, Nguyen THD
Nature 2021 May;593(7859):449-453
Nature 2021 May;593(7859):449-453
SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization.
MacNeil DE, Lambert-Lanteigne P, Qin J, McManus FP, Bonneil E, Thibault P, Autexier C
Molecular and cellular biology 2021 Mar 24;41(4)
Molecular and cellular biology 2021 Mar 24;41(4)
NHP2 downregulation counteracts hTR-mediated activation of the DNA damage response at ALT telomeres.
Raghunandan M, Geelen D, Majerova E, Decottignies A
The EMBO journal 2021 Mar 15;40(6):e106336
The EMBO journal 2021 Mar 15;40(6):e106336
N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation.
MacNeil DE, Lambert-Lanteigne P, Autexier C
Nucleic acids research 2019 Jun 4;47(10):5368-5380
Nucleic acids research 2019 Jun 4;47(10):5368-5380
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
Nguyen THD, Tam J, Wu RA, Greber BJ, Toso D, Nogales E, Collins K
Nature 2018 May;557(7704):190-195
Nature 2018 May;557(7704):190-195
Differential requirements for H/ACA ribonucleoprotein components in cell proliferation and response to DNA damage.
Lin P, Mobasher ME, Hakakian Y, Kakarla V, Naseem AF, Ziai H, Alawi F
Histochemistry and cell biology 2015 Dec;144(6):543-58
Histochemistry and cell biology 2015 Dec;144(6):543-58
Expressional analysis of NOLA1, NOLA2, NOLA3 and DKC1, the core proteins in H/ACA riboproteins, in gastric and colorectal cancers.
Kim MS, Kim SS, Yoo NJ, Lee SH
Pathology 2012 Oct;44(6):576-7
Pathology 2012 Oct;44(6):576-7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A375 cells were subjected to SDS PAGE followed by western blot with 15128-1-AP(NHP2 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using NHP2 antibody 15128-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 15128-1-AP(NHP2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 15128-1-AP(NHP2 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue