Antibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 15128-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15128-1-AP, RRID:AB_2267290
- Product name
- NHP2 antibody
- Antibody type
- Polyclonal
- Description
- NHP2 antibody (Cat. #15128-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The C-terminal extension of dyskerin is a dyskeratosis congenita mutational hotspot that modulates interaction with telomerase RNA and subcellular localization.
ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells.
Proteomic analyses reveal new features of the box H/ACA RNP biogenesis.
Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex.
Nhp2 is a reader of H2AQ105me and part of a network integrating metabolism with rRNA synthesis.
Structure of human telomerase holoenzyme with bound telomeric DNA.
SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization.
NHP2 downregulation counteracts hTR-mediated activation of the DNA damage response at ALT telomeres.
Comparative Proteomic Analysis of tPVAT during Ang II Infusion.
N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation.
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
Differential requirements for H/ACA ribonucleoprotein components in cell proliferation and response to DNA damage.
Expressional analysis of NOLA1, NOLA2, NOLA3 and DKC1, the core proteins in H/ACA riboproteins, in gastric and colorectal cancers.
A spectrum of oncocytic lesions in the parotid gland of a patient with sarcoidosis.
Qin J, Garus A, Autexier C
Human molecular genetics 2024 Feb 1;33(4):318-332
Human molecular genetics 2024 Feb 1;33(4):318-332
ZNF692 organizes a hub specialized in 40S ribosomal subunit maturation enhancing translation in rapidly proliferating cells.
Lafita-Navarro MC, Hao YH, Jiang C, Jang S, Chang TC, Brown IN, Venkateswaran N, Maurais E, Stachera W, Zhang Y, Mundy D, Han J, Tran VM, Mettlen M, Xu L, Woodruff JB, Grishin NV, Kinch L, Mendell JT, Buszczak M, Conacci-Sorrell M
Cell reports 2023 Oct 31;42(10):113280
Cell reports 2023 Oct 31;42(10):113280
Proteomic analyses reveal new features of the box H/ACA RNP biogenesis.
Schlotter F, Mérouani S, Flayac J, Kogey V, Issa A, Dodré M, Huttin A, Branlant C, Bertrand E, Labialle S, Vandermoere F, Verheggen C, Massenet S
Nucleic acids research 2023 Apr 24;51(7):3357-3374
Nucleic acids research 2023 Apr 24;51(7):3357-3374
Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex.
Han C, Sun LY, Luo XQ, Pan Q, Sun YM, Zeng ZC, Chen TQ, Huang W, Fang K, Wang WT, Chen YQ
Cell reports 2022 Mar 29;38(13):110421
Cell reports 2022 Mar 29;38(13):110421
Nhp2 is a reader of H2AQ105me and part of a network integrating metabolism with rRNA synthesis.
Mawer JSP, Massen J, Reichert C, Grabenhorst N, Mylonas C, Tessarz P
EMBO reports 2021 Oct 5;22(10):e52435
EMBO reports 2021 Oct 5;22(10):e52435
Structure of human telomerase holoenzyme with bound telomeric DNA.
Ghanim GE, Fountain AJ, van Roon AM, Rangan R, Das R, Collins K, Nguyen THD
Nature 2021 May;593(7859):449-453
Nature 2021 May;593(7859):449-453
SUMOylation- and GAR1-Dependent Regulation of Dyskerin Nuclear and Subnuclear Localization.
MacNeil DE, Lambert-Lanteigne P, Qin J, McManus FP, Bonneil E, Thibault P, Autexier C
Molecular and cellular biology 2021 Mar 24;41(4)
Molecular and cellular biology 2021 Mar 24;41(4)
NHP2 downregulation counteracts hTR-mediated activation of the DNA damage response at ALT telomeres.
Raghunandan M, Geelen D, Majerova E, Decottignies A
The EMBO journal 2021 Mar 15;40(6):e106336
The EMBO journal 2021 Mar 15;40(6):e106336
Comparative Proteomic Analysis of tPVAT during Ang II Infusion.
Liang X, Guan H, Sun J, Qi Y, Yao W
Biomedicines 2021 Dec 2;9(12)
Biomedicines 2021 Dec 2;9(12)
N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation.
MacNeil DE, Lambert-Lanteigne P, Autexier C
Nucleic acids research 2019 Jun 4;47(10):5368-5380
Nucleic acids research 2019 Jun 4;47(10):5368-5380
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
Nguyen THD, Tam J, Wu RA, Greber BJ, Toso D, Nogales E, Collins K
Nature 2018 May;557(7704):190-195
Nature 2018 May;557(7704):190-195
Differential requirements for H/ACA ribonucleoprotein components in cell proliferation and response to DNA damage.
Lin P, Mobasher ME, Hakakian Y, Kakarla V, Naseem AF, Ziai H, Alawi F
Histochemistry and cell biology 2015 Dec;144(6):543-58
Histochemistry and cell biology 2015 Dec;144(6):543-58
Expressional analysis of NOLA1, NOLA2, NOLA3 and DKC1, the core proteins in H/ACA riboproteins, in gastric and colorectal cancers.
Kim MS, Kim SS, Yoo NJ, Lee SH
Pathology 2012 Oct;44(6):576-7
Pathology 2012 Oct;44(6):576-7
A spectrum of oncocytic lesions in the parotid gland of a patient with sarcoidosis.
Ziad F, Sinha S, White J, Pandya H
Pathology 2012 Oct;44(6):574-6
Pathology 2012 Oct;44(6):574-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A375 cells were subjected to SDS PAGE followed by western blot with 15128-1-AP(NHP2 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using NHP2 antibody 15128-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 15128-1-AP(NHP2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 15128-1-AP(NHP2 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue