Tissue expression
Cell line expression
Protein structure
DOCK3
Dedicator of cytokinesis 3KIAA0299, MOCA, PBP
This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
Top validated antibodies |
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Proteintech Group | 20683-1-AP | 2 references | Polyclonal |
WB
EL
IHC
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Atlas Antibodies | HPA037543 | Polyclonal |
WB
ICC
IHC
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Biorbyt | orb156627 | Polyclonal |
WB
EL
ICC
IHC |
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Invitrogen Antibodies | PA5-57996 | Polyclonal |
WB
ICC
IHC
|
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Abnova Corporation | PAB23128 | Polyclonal |
WB
ICC
IHC
|
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