NLRP8

This gene encodes a member of the nucleotide-binding oligomerization domain/ leucine rich repeat/ pyrin domain containing (NLRP) subfamily, which belongs to the Nod-like receptor family of proteins. NLRP genes play roles in the mammalian innate immune system through inflammasome formation and activation of caspases. In addition, NLRP genes have been found to function during mammalian reproduction. Consistent with a function during human preimplantation development, this gene is expressed at high levels in oocytes with decreased levels in embryos. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Description

NLR family pyrin domain containing 8

Tissue specificity

Not detected

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

19 (55947832 - 55988629)

Ensembl ID

ENSG00000179709  (ver. 103.38)

Orthologs

-

UniProt

Q86W28

neXtProt

NX_Q86W28

Human splice variants

Protein structure