Antibody data

Product number
BS60257 - Provider product page
Provider
Bioworld Technology, Inc
Product name
BBP polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human BBP.
Description
Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the ÉÇ-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer£ªs disease. Proteolytic cleavage of APP leads to the formation of the Amyloid ÉÇ/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer£ªs patients. BBP (Beta-amyloid-binding protein), also known as TM2D1 (TM2 domain-containing protein 1), is a 207 amino acid multi-pass membrane protein containing a G protein-coupling module that allows for interaction with the ÉÇ-amyloid peptide of APP. In cell culture, expression of BBP induces caspase-dependent vulnerability to ÉÇ-amyloid peptide toxicity, suggesting that it is a target of ÉÇ-amyloid and may be involved in the molecular pathophysiology of Alzheimer£ªs disease.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
TM2D1 protein structure - BS60257 shown in red.