APR03554G

antibody from Leading Biology

Targeting: PSMB11 beta5t

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APR03554G

Provider

Leading Biology

Product name

PSMB11 Antibody (C-term)

Antibody type

Polyclonal

Description

Proteasomes generate peptides that are presented by majorhistocompatibility complex (MHC) I molecules to other cells of theimmune system. Proteolysis is conducted by 20S proteasomes,complexes of 28 subunits arranged as a cylinder in 4heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7,and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM600306). Three additional subunits, beta-1i (PSMB9; MIM 177045),beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), areinduced by gamma-interferon (IFNG; MIM 147570) and arepreferentially incorporated into proteasomes to makeimmunoproteasomes. PSMB11, or beta-5t, is a catalytic subunitexpressed exclusively in cortical thymic epithelial cells (Murataet al., 2007 [PubMed 17540904]).

Reactivity

Human

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.