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Cell line expression
Protein structure
CCDC88A
Coiled-coil domain containing 88AAPE, FLJ10392, GIV, GRDN, HkRP1, KIAA1212
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Top validated antibodies |
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| NovoPro Bioscience Inc. |  122168 |
Polyclonal |
WB
EL
ICC
IHC
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| LSBio | LS-C761184 |
Polyclonal |
WB
IHC
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| antibodies-online | ABIN499889 |
5 references | Polyclonal |
WB
EL
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| OriGene | AP23928PU-N |
Polyclonal |
WB
EL
IHC
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| NSJ Bioreagents | RQ7828 |
Polyclonal |
WB
EL
FC
|
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