PUS10

Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]). [supplied by OMIM, May 2009]

Description

Pseudouridine synthase 10

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Mitochondria

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (60940222 - 61018259)

Ensembl ID

ENSG00000162927  (ver. 103.38)

Orthologs

Mouse Pus10: ENSMUSG00000020280

UniProt

Q3MIT2

neXtProt

NX_Q3MIT2

Human splice variants
Mouse splice variants

Protein structure