MITD1

Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Description

Microtubule interacting and trafficking domain containing 1

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (99161427 - 99181058)

Ensembl ID

ENSG00000158411  (ver. 103.38)

Orthologs

Mouse Mitd1: ENSMUSG00000026088

UniProt

Q8WV92

neXtProt

NX_Q8WV92

Human splice variants
Mouse splice variants

Protein structure