Tissue expression
Cell line expression
Protein structure
PLEKHM2
Pleckstrin homology and RUN domain containing M2KIAA0842
This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. [provided by RefSeq, Feb 2017]
Top validated antibodies |
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Invitrogen Antibodies | PA5-20850 | 2 references | Polyclonal |
WB
ICC
IHC
OA |
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Novus Biologicals | NBP1-77089 | Polyclonal |
WB
EL
ICC
IHC |
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Boster Biological Technology | A11280 | Polyclonal |
WB
EL
ICC
IHC |
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NovoPro Bioscience Inc. | 122018 | Polyclonal |
WB
EL
ICC
IHC |
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antibodies-online | ABIN4346196 | Polyclonal |
WB
EL
ICC
IHC |
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Recommended by provider