SLC4A10

This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2010]

Description

Solute carrier family 4 member 10

Tissue specificity

Tissue enhanced (brain, choroid plexus, retina)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

2 (161424332 - 161985282)

Ensembl ID

ENSG00000144290  (ver. 103.38)

Orthologs

Mouse Slc4a10: ENSMUSG00000026904

UniProt

Q6U841

neXtProt

NX_Q6U841

Human splice variants
Mouse splice variants

Protein structure