11733-1-AP
antibody from Proteintech Group
Targeting: CUX1
CASP, CDP, CDP/Cut, CDP/Cux, CDP1, Clox, CUT, CUTL1, CUX, Cux/CDP, GOLIM6
Antibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
Reference
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- Product number
- 11733-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11733-1-AP, RRID:AB_2086995
- Product name
- CUX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CUX1 antibody (Cat. #11733-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Restoration of Visual Function and Cortical Connectivity After Ischemic Injury Through NeuroD1-Mediated Gene Therapy.
CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.
Neuroserpin Is Strongly Expressed in the Developing and Adult Mouse Neocortex but Its Absence Does Not Perturb Cortical Lamination and Synaptic Proteome.
RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity.
IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype.
Cellular and Behavioral Characterization of Pcdh19 Mutant Mice: subtle Molecular Changes, Increased Exploratory Behavior and an Impact of Social Environment.
Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.
Overexpressed P75CUX1 promotes EMT in glioma infiltration by activating β-catenin.
Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision between Stem Cell Maintenance and Differentiation.
ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.
AIF3 splicing switch triggers neurodegeneration.
Liquid Biopsy of Extracellular Vesicle-Derived miR-193a-5p in Colorectal Cancer and Discovery of Its Tumor-Suppressor Functions.
hGFAP-Positive Stem Cells Depend on Brg1 for Proper Formation of Cerebral and Cerebellar Structures.
Reversing a model of Parkinson's disease with in situ converted nigral neurons.
The basic helix-loop-helix transcription factor TCF4 impacts brain architecture as well as neuronal morphology and differentiation.
PRISM: A Progenitor-Restricted Intersectional Fate Mapping Approach Redefines Forebrain Lineages.
Large-Area Fluorescence and Electron Microscopic Correlative Imaging With Multibeam Scanning Electron Microscopy.
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
A trap mutant reveals the physiological client spectrum of TRC40.
Upregulated Expression of CUX1 Correlates with Poor Prognosis in Glioma Patients: a Bioinformatic Analysis.
Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice.
Inactivating CUX1 mutations promote tumorigenesis.
Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.
Tang Y, Wu Q, Gao M, Ryu E, Pei Z, Kissinger ST, Chen Y, Rao AK, Xiang Z, Wang T, Li W, Chen G, Chubykin AA
Frontiers in cell and developmental biology 2021;9:720078
Frontiers in cell and developmental biology 2021;9:720078
CUX1 Facilitates the Development of Oncogenic Properties Via Activating Wnt/β-Catenin Signaling Pathway in Glioma.
Feng F, Zhao Z, Zhou Y, Cheng Y, Wu X, Heng X
Frontiers in molecular biosciences 2021;8:705008
Frontiers in molecular biosciences 2021;8:705008
Neuroserpin Is Strongly Expressed in the Developing and Adult Mouse Neocortex but Its Absence Does Not Perturb Cortical Lamination and Synaptic Proteome.
Kement D, Reumann R, Schostak K, Voß H, Douceau S, Dottermusch M, Schweizer M, Schlüter H, Vivien D, Glatzel M, Galliciotti G
Frontiers in neuroanatomy 2021;15:627896
Frontiers in neuroanatomy 2021;15:627896
RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity.
Proietti Onori M, Koene LMC, Schäfer CB, Nellist M, de Brito van Velze M, Gao Z, Elgersma Y, van Woerden GM
PLoS biology 2021 May;19(5):e3001279
PLoS biology 2021 May;19(5):e3001279
IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype.
Hayano Y, Ishino Y, Hyun JH, Orozco CG, Steinecke A, Potts E, Oisi Y, Thomas CI, Guerrero-Given D, Kim E, Kwon HB, Kamasawa N, Taniguchi H
Science advances 2021 Jul;7(29)
Science advances 2021 Jul;7(29)
Cellular and Behavioral Characterization of Pcdh19 Mutant Mice: subtle Molecular Changes, Increased Exploratory Behavior and an Impact of Social Environment.
Galindo-Riera N, Newbold SA, Sledziowska M, Llinares-Benadero C, Griffiths J, Mire E, Martinez-Garay I
eNeuro 2021 Jul-Aug;8(4)
eNeuro 2021 Jul-Aug;8(4)
Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.
Phan TP, Maryniak AL, Boatwright CA, Lee J, Atkins A, Tijhuis A, Spierings DC, Bazzi H, Foijer F, Jordan PW, Stracker TH, Holland AJ
The EMBO journal 2021 Jan 4;40(1):e106118
The EMBO journal 2021 Jan 4;40(1):e106118
Overexpressed P75CUX1 promotes EMT in glioma infiltration by activating β-catenin.
Xu A, Wang X, Luo J, Zhou M, Yi R, Huang T, Lin J, Wu Z, Xie C, Ding S, Zeng Y, Song Y
Cell death & disease 2021 Feb 4;12(2):157
Cell death & disease 2021 Feb 4;12(2):157
Differential Expression Levels of Sox9 in Early Neocortical Radial Glial Cells Regulate the Decision between Stem Cell Maintenance and Differentiation.
Fabra-Beser J, Alves Medeiros de Araujo J, Marques-Coelho D, Goff LA, Costa MR, Müller U, Gil-Sanz C
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Aug 18;41(33):6969-6986
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Aug 18;41(33):6969-6986
ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex.
Medeiros de Araújo JA, Barão S, Mateos-White I, Espinosa A, Costa MR, Gil-Sanz C, Müller U
Development (Cambridge, England) 2021 Aug 15;148(16)
Development (Cambridge, England) 2021 Aug 15;148(16)
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CC
Nature communications 2021 Apr 30;12(1):2482
Nature communications 2021 Apr 30;12(1):2482
AIF3 splicing switch triggers neurodegeneration.
Liu S, Zhou M, Ruan Z, Wang Y, Chang C, Sasaki M, Rajaram V, Lemoff A, Nambiar K, Wang JE, Hatanpaa KJ, Luo W, Dawson TM, Dawson VL, Wang Y
Molecular neurodegeneration 2021 Apr 14;16(1):25
Molecular neurodegeneration 2021 Apr 14;16(1):25
Liquid Biopsy of Extracellular Vesicle-Derived miR-193a-5p in Colorectal Cancer and Discovery of Its Tumor-Suppressor Functions.
Wei R, Chen L, Qin D, Guo Q, Zhu S, Li P, Min L, Zhang S
Frontiers in oncology 2020;10:1372
Frontiers in oncology 2020;10:1372
hGFAP-Positive Stem Cells Depend on Brg1 for Proper Formation of Cerebral and Cerebellar Structures.
Holdhof D, Schoof M, Hellwig M, Holdhof NH, Niesen J, Schüller U
Cerebral cortex (New York, N.Y. : 1991) 2020 Mar 14;30(3):1382-1392
Cerebral cortex (New York, N.Y. : 1991) 2020 Mar 14;30(3):1382-1392
Reversing a model of Parkinson's disease with in situ converted nigral neurons.
Qian H, Kang X, Hu J, Zhang D, Liang Z, Meng F, Zhang X, Xue Y, Maimon R, Dowdy SF, Devaraj NK, Zhou Z, Mobley WC, Cleveland DW, Fu XD
Nature 2020 Jun;582(7813):550-556
Nature 2020 Jun;582(7813):550-556
The basic helix-loop-helix transcription factor TCF4 impacts brain architecture as well as neuronal morphology and differentiation.
Schoof M, Hellwig M, Harrison L, Holdhof D, Lauffer MC, Niesen J, Virdi S, Indenbirken D, Schüller U
The European journal of neuroscience 2020 Jun;51(11):2219-2235
The European journal of neuroscience 2020 Jun;51(11):2219-2235
PRISM: A Progenitor-Restricted Intersectional Fate Mapping Approach Redefines Forebrain Lineages.
Poulin JF, Luppi MP, Hofer C, Caronia G, Hsu PK, Chan CS, Awatramani R
Developmental cell 2020 Jun 22;53(6):740-753.e3
Developmental cell 2020 Jun 22;53(6):740-753.e3
Large-Area Fluorescence and Electron Microscopic Correlative Imaging With Multibeam Scanning Electron Microscopy.
Shibata S, Iseda T, Mitsuhashi T, Oka A, Shindo T, Moritoki N, Nagai T, Otsubo S, Inoue T, Sasaki E, Akazawa C, Takahashi T, Schalek R, Lichtman JW, Okano H
Frontiers in neural circuits 2019;13:29
Frontiers in neural circuits 2019;13:29
TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
Ivanova EL, Gilet JG, Sulimenko V, Duchon A, Rudolf G, Runge K, Collins SC, Asselin L, Broix L, Drouot N, Tilly P, Nusbaum P, Vincent A, Magnant W, Skory V, Birling MC, Pavlovic G, Godin JD, Yalcin B, Hérault Y, Dráber P, Chelly J, Hinckelmann MV
Nature communications 2019 May 13;10(1):2129
Nature communications 2019 May 13;10(1):2129
A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science 2019 Jul 1;132(13)
Journal of cell science 2019 Jul 1;132(13)
Upregulated Expression of CUX1 Correlates with Poor Prognosis in Glioma Patients: a Bioinformatic Analysis.
Wu X, Feng F, Yang C, Zhang M, Cheng Y, Zhao Y, Wang Y, Che F, Zhang J, Heng X
Journal of molecular neuroscience : MN 2019 Dec;69(4):527-537
Journal of molecular neuroscience : MN 2019 Dec;69(4):527-537
Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice.
Yu B, Jin Y, Shen Y, Yang Y, Wang G, Zhu H, Yu Y, Wang J
Biochemical and biophysical research communications 2019 Aug 13;516(1):229-235
Biochemical and biophysical research communications 2019 Aug 13;516(1):229-235
Inactivating CUX1 mutations promote tumorigenesis.
Wong CC, Martincorena I, Rust AG, Rashid M, Alifrangis C, Alexandrov LB, Tiffen JC, Kober C, Chronic Myeloid Disorders Working Group of the International Cancer Genome Consortium., Green AR, Massie CE, Nangalia J, Lempidaki S, Döhner H, Döhner K, Bray SJ, McDermott U, Papaemmanuil E, Campbell PJ, Adams DJ
Nature genetics 2014 Jan;46(1):33-8
Nature genetics 2014 Jan;46(1):33-8
Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.
Gokhale A, Larimore J, Werner E, So L, Moreno-De-Luca A, Lese-Martin C, Lupashin VV, Smith Y, Faundez V
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Mar 14;32(11):3697-711
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Mar 14;32(11):3697-711
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 11733-1-AP(CUX1 antibody) at dilution of 1:2000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CUX1 antibody 11733-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line