APR01814G

antibody from Leading Biology

Targeting: NSMCE4A bA500G22.3, C10orf86, FLJ20003, NSE4A

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

APR01814G

Provider

Leading Biology

Product name

NSMCE4A Antibody - C-terminal region

Antibody type

Polyclonal

Description

Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus.

Reactivity

Human, Mouse, Rat, Bovine, Canine, Guinea Pig, Horse, Rabbit

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.