WHAMM

This gene encodes a protein that plays a role in actin nucleation, Golgi membrane association and microtubule binding. The encoded protein is a nucleation-promoting factor that regulates the Actin-related protein 2/3 complex. The activated complex initiates growth of new actin filaments by binding to existing actin filaments. The encoded protein also functions in regulation of transport from the endoplasmic reticulum to the Golgi complex and in maintenance of the Golgi complex near the centrosome. Four pseudogenes of this gene are present on the same arm of chromosome 15 as this gene. [provided by RefSeq, Aug 2013]

Description

WASP homolog associated with actin, golgi membranes and microtubules

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

15 (82809628 - 82836108)

Ensembl ID

ENSG00000156232  (ver. 103.38)

Orthologs

Mouse Whamm: ENSMUSG00000045795

UniProt

Q8TF30

neXtProt

NX_Q8TF30

Human splice variants
Mouse splice variants

Protein structure