BTNL2

This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017]

Description

Butyrophilin like 2

Tissue specificity

Not detected

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

6 (32393963 - 32407128)

Ensembl ID

ENSG00000204290  (ver. 103.38)

Orthologs

Mouse Btnl2: ENSMUSG00000024340

UniProt

Q9UIR0

neXtProt

NX_Q9UIR0

Human splice variants
Mouse splice variants

Protein structure