Tissue expression
Cell line expression
Protein structure
VKORC1
Vitamin K epoxide reductase complex subunit 1VKCFD2
This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Top validated antibodies |
|||||
LSBio | LS-C153685 | Polyclonal |
WB
EL
ICC
IHC |
||
Invitrogen Antibodies | PA5-60093 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
GeneTex | GTX47837 | Polyclonal |
WB
EL
ICC
IP
IHC
|
||
Boster Biological Technology | A01059 | Polyclonal |
WB
EL
ICC
IHC |
||
antibodies-online | ABIN1450145 | 1 references | Polyclonal |
WB
ICC
IHC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider