Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 340602 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#340602, RRID:AB_2074123
- Product name
- Purified anti-human CD300F (IREM-1)
- Antibody type
- Monoclonal
- Antigen
- CD300F
- Description
- IREM-1 (immune receptor expressed by myeloid cell 1) is a type I single transmembrane protein encoded by human chromosome 17q24.25. A member of the CD300 (CMRF-35) family and the Ig superfamily, IREM-1 is also known as CD300F, or CD300LF (CD300-like member F). CD300F is expressed on monocytes, granulocytes, and myeloid leukemia cell lines. The cytoplasmic domain of IREM-1 contains an ITIM and associates with the P85α subunit of PI3K (phosphoinositide 3-kinase). IREM-1 also functions as an inhibitory receptor.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references CD300F blocks both MyD88 and TRIF-mediated TLR signaling through activation of Src homology region 2 domain-containing phosphatase 1.
Lee SM, Kim EJ, Suk K, Lee WH
Journal of immunology (Baltimore, Md. : 1950) 2011 Jun 1;186(11):6296-303
Journal of immunology (Baltimore, Md. : 1950) 2011 Jun 1;186(11):6296-303
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood monocytes stained with UP-D2 PE
- Conjugate
- Unconjugated