OLFML3

This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-terminal olfactomedin domain that facilitates protein-protein interactions, cell adhesion, and intercellular interactions. It serves as both a scaffold protein that recruits bone morphogenetic protein 1 to its substrate chordin, and as a vascular tissue remodeler with pro-angiogenic properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Description

Olfactomedin like 3

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (113979391 - 114035572)

Ensembl ID

ENSG00000116774  (ver. 103.38)

Orthologs

Mouse Olfml3: ENSMUSG00000027848

UniProt

Q9NRN5

neXtProt

NX_Q9NRN5

Human splice variants
Mouse splice variants

Protein structure